Regulation of the Epithelial Sodium Channel (ENaC) by the Short Palate, Lung, and Nasal Epithelial Clone (SPLUNC1)

............................................................................35 Introduction.........................................................................36 Results...............................................................................38 Discussion...........................................................................40 Methods..............................................................................43 Figures...............................................................................46 IV. ACIDIC ENVIRONEMNTS, LIKE THOSE IN CYSTIC FIBROSIS AIRWAYS, PREVENT SPLUNC1’S INHIBITION OF ENAC.........................................53 Abstract.............................................................................53 Introduction.........................................................................54 Results...............................................................................56 Discussion...........................................................................58 Methods..............................................................................28 Figures...............................................................................64 V. Summary............................................................................72 VII. Appendix............................................................................75